![]() ![]() Numerous animal studies and human clinical trials have demonstrated that chromium picolinate supplements are safe. Chromium picolinate is the most efficacious form of chromium supplementation. Supplements containing 200-1,000 mcg chromium as chromium picolinate a day have been found to improve blood glucose control. Chromium picolinate, specifically, has been shown to reduce insulin resistance and to help reduce the risk of cardiovascular disease and type 2 diabetes. Several studies have now demonstrated that chromium supplements enhance the metabolic action of insulin and lower some of the risk factors for cardiovascular disease, particularly in overweight individuals. Chromium has no known serious interactions with other drugs. 1 If you’re on insulin, anti-diabetes medications, or levothyroxine, talk to your doctor before taking a chromium picolinate supplement.Chromium has no known severe interactions with other drugs. Insulin resistance is present in two serious health problems in women polycystic ovarian syndrome (PCOS) and gestational diabetes. But chromium picolinate should not be used by people with kidney or liver disease. Insulin resistance, with or without the presence of metabolic syndrome, significantly increases the risk of cardiovascular disease. It affects 40% of people in their 60s and 70s. One out of every five Americans has metabolic syndrome. ![]() Insulin resistance is the common denominator in a cluster of cardiovascular disease risk factors. Studies show that people with type 2 diabetes have lower blood levels of chromium than those without the disease. Chromium is an important factor for enhancing insulin activity. No one should take more than 300 mcg per day of chromium without the supervision of a doctor.Chromium is an essential mineral that appears to have a beneficial role in the regulation of insulin action and its effects on carbohydrate, protein and lipid metabolism. 15 Whether these problems were caused by chromium picolinate or, if so, whether other forms of chromium might have the same effects at these high amounts remains unclear. 14 A case of a muscle disease known as rhabdomyolysis appeared in a body builder who took 1200 mcg over 48 hours. 13 A case of anemia, liver dysfunction, and other problems appeared after four to five months of 1,200–2,400 mcg per day. A case of kidney failure appeared after taking 600 mcg per day for six weeks. Three single, unrelated cases of toxicity have been reported from use of chromium picolinate. 12 However, no published evidence supports this assertion. What Is Chromium For May promote glucose metabolism May support weight loss programmes by reducing sugar cravings May improve heart health May help to. Another source claimed that there have been reports of mild heart rhythm abnormalities with excessive chromium ingestion. 11 However, chromium supplementation was not proven to be the cause of these problems. One report of severe illness (including liver and kidney damage) occurring in a person who was taking 1,000 mcg of chromium per day has been reported. 9 In theory, these changes could increase the risk of cancer, but so far, chromium intake has not been linked to increased incidence of cancer in humans. Chromium picolinate is a supplement that some people take as a complementary and alternative therapy to help a chromium deficiency, control blood sugar levels, lower cholesterol, or lose. ![]() 7, 8 Chromium picolinate can be altered by antioxidants or hydrogen peroxide in the body to a form that could itself create free radical damage. One study suggested that chromium in very high concentrations in a test tube could cause chromosomal mutations in ovarian cells of hamsters. ![]() While there are a few reports of people developing medical problems while taking chromium, a cause-effect relationship was not proven. In supplemental amounts (typically 50–300 mcg per day), chromium has not been found to cause toxicity in humans. ![]()
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